GATE Syllabus for Biotechnology (BT) 2018

Last Updated - March 09 2018

Biotechnology is covered in different engineering disciplines like Bioinformatics, Biomedical engineering and in biotechnology itself. Exam format for GATE Biotechnology is same as that of Biomedical and Bioinformatics. GATE will be organizeed in the online method as a Computer Based Test and will have multiple-choice questions. Aspirants will be given 3 hours to clear the exam. 

  • GATE 2018 is scheduled for February 03, 04, 10 and 11, 2018. 
  • A proper GATE Paper Analysis must be done by the aspirants about the sections are covered in the exams and must exclude the unworthy sections.
  • GATE Exam Format consists of 3 sections namely General Aptitude, Engineering Mathematics and specific subject of the paper.
  • GATE Biotechnology Syllabus will comprise Engineering Mathematics, Biotechnology, Recombinant DNA Technology, Plant and Animal Biotechnology and Bioprocedure Engineering and Procedure Biotechnology.

GATE Exam Format will consist of total 65 questions and an aspirant can score maximum 100 marks in the exam. No marks will be deducted for any wrong response. GATE will be held in 2 shifts (Morning and Afternoon).

It is very important for an aspirant to know the GATE 2017 Exam Format so that he or she can know the type and number of questions asked in the exam.

GATE Biotechnology Syllabus for 2018

GATE 2018 for Biotechnology program will have questions from topics such as Engineering Mathematics, Biotechnology, Recombinant DNA Technology, Plant and Animal Biotechnology and Bioprocedure Engineering and Procedure Biotechnology. to study these topics, aspirants can refer to the best Preparation Books for GATE.

Section-wise syllabus of GATE 2018 is explained below.

Section. 1 Engineering Mathematics

Linear AlgebraMatrices and determinants, Systems of linear equations, Eigenvalues and Eigenvectors
CalculusLimit, continuity and differentiability, Partial derivatives, Maxima and minima, Sequences and series, Test for convergence, Fourier series
Differential EquationsLinear and nonlinear first order ODEs, higher order ODEs with constant coefficients, Cauchy's and Euler's equations, Laplace transforms, PDE- Laplace, heat, and wave equations
Probability and StatisticsMean, median, method and standard deviation, Random variables, Poisson, normal and binomial distributions, Correlation and regression analysis
Numerical MethodsSolution of linear and nonlinear algebraic equations, Integration of trapezoidal and Simpson's rule, Single and multi-step methods for differential equation

Section. 2 Biotechnology

MicrobiologyProkaryotic and eukaryotic cell structure; Microbial nutrition, growth, and control; Microbial metabolism (aerobic and anaerobic respiration, photosynthesis); Nitrogen fixation; the Chemical basis of mutations and mutagens; Microbial genetics (plasmids, transformation, transduction, conjugation); Microbial diversity and characteristic features; Viruses.
BiochemistryBiomolecules and their conformation; Weak inter-molecular interactions in biomacromolecules; Chemical and functional nature of enzymes; Kinetics of a single substrate and bi-substrate-enzyme-catalyzed reactions; Bioenergetics; Metabolism (Glycolysis, TCA, and Oxidative phosphorylation); Membrane transport and pumps; Cell cycle and cell growth control; Cell signalling and signal transduction.
Molecular Biology and GeneticsMolecular structure of genes and chromosomes; DNA replication and control; Transcription and its control; Translational procedures; Regulatory controls in prokaryotes and eukaryotes; Mendelian inheritance; Gene interaction; Complementation; Linkage, recombination and chromosome mapping; Extrachromosomal inheritance; Chromosomal variation; Population genetics; Transposable elements, Molecular basis of genetic diseases and applications.
Analytical TechniquesPrinciples of microscopy-light, electron, fluorescent and confocal; Centrifugation- high-speed and ultra; Principles of spectroscopy-UV, visible, CD, IR, FTIR, Raman, MS, NMR; Principles of chromatography- ion exchange, gel filtration, hydrophobic interaction, affinity, GC, HPLC, FPLC; Electrophoresis; Microarray
ImmunologyThe origin of Immunology; Inherent immunity; Humoral and cell-mediated immunity; Primary and secondary lymphoid organ; Antigen; B and T cells and Macrophages; Major histocompatibility complex (MHC); Antigen procedures and presentation; Synthesis of antibody and secretion; Molecular basis of antibody diversity; Polyclonal and monoclonal antibody; Complement; Antigen-antibody reaction; Regulation of immune answer; Immune tolerance; Hypersensitivity; Autoimmunity; Graft versus host reaction.
BioinformaticsMajor Bioinformatics resources (NCBI, EBI, ExPASy); Sequence and structure databases; Sequence analysis (Bio-molecular sequence file patterns, scoring matrices, sequence alignment, phylogeny); Genomics and Proteomics (Large-scale genome sequencing strategies; Comparative genomics; Understanding DNA microarrays and protein arrays); Molecular modeling and simulations (basic concepts including concept of force fields)

Section. 3 Recombinant DNA Technology

Restriction and modification enzymes; Vectors: plasmid, bacteriophage and other viral vectors, cosmids, Ti plasmid, yeast artificial chromosome; cDNA and genomic DNA library; Gene isolation; Gene cloning; Expression of cloned gene; Transposons and gene targeting; DNA labeling; DNA sequencing; Polymerase chain reactions; DNA fingerprinting; Southern and northern blotting; In- situ hybridization; RAPD; RFLP; Site-directed mutagenesis; Gene transfer technologies; Gene therapy.

Section. 4 Plant and Animal Biotechnology

  • Totipotency Regeneration of plants; Plant growth regulators and elicitors; Tissue culture and Cell suspension culture system: methodology, kinetics of growth and, nutrient optimization; Production of secondary metabolites by plant suspension cultures; Hairy root culture; transgenic plants; Plant products of industrial importance Animal cell culture; media composition and growth conditions;
  • Animal cell and tissue preservation; Anchorage and non-anchorage dependent cell culture; Kinetics of cell growth; Micro & macro-carrier culture; Hybridoma technology; Stem cell technology; Animal cloning; Transgenic animals

Section. 5 Bioprocedure Engineering and Procedure Biotechnology

  • Rheology of fermentation fluids, Aeration and agitation; Media formulation and optimization; Kinetics of microbial growth, substrate utilization and product pattern; Sterilization of air and media; Batch, fed-batch and continuous procedures; different types of microbial and enzyme reactors; Instrumentation control and optimization; Unit operations in solid-liquid separation and liquid-liquid extraction; Procedure scale-up, economics and feasibility analysis
  • Engineering principle of bio procedures- Upstream production and downstream; Bioprocedure design and development from lab to industrial scale; Microbial, animal and plant cell culture platforms; Production of biomass and primary/secondary metabolites; Biofuels, Bio-plastics, industrial enzymes, antibiotics; Large-scale production and purification of recombinant proteins; Industrial application of chromatographic and membrane-based bio-separation methods; Immobilization of biocatalysts (enzymes and cells) for bioconversion procedures; Bioremediation-Aerobic and anaerobic procedures for stabilization of solid / liquid wastes
  • Chemical engineering principles applied to the biological system, Principle of reactor design, ideal and non-ideal multiphase bioreactors, mass and heat transfer

As there will be various papers for different branches, so aspirants must solve GATE Exercise Papers to focus on understanding for an extensive the candidates to score well in the exam.

GATE Earlier Year Papers for Biotechnology 2018

It is very important for an aspirant to exercise GATE 2018 Earlier Year Papers for Biotechnology so that they can idea regarding the type of questions asked in the exam. Take a note of the errors done and try not to repeat them again. It also helps in improving the speed of the aspirant. The aspirant must exercise using a stopwatch to improve the speed.

Advisable Books for GATE 2018

Aspirants can exercise from some of the best books advisable for GATE 2018 mentioned below:

  • GATE 2018 Guide Biotechnology (Author-G.K.P; Publisher- G.K. Publisher)
  • Biotechnology for CSIR- NET, SET, GATE, JNU, AIIMS, JAM (Author-Vinita Thakur; Publisher- Himalaya Publication House)
  • Biotechnology GATE 2018 (Author-B.M. Agarwal, Akanksha Singhal, Vidhika Goel; Publisher-Arihant Publications)

GATE 2018 exam will have Virtual Calculator for the aspirants for making calculation during the exam. Apart from practising earlier years’ papers, aspirants must also learn to use GATE 2018 Virtual Calculator. It was first introduced last year for the aspirants as they brought a physical calculator for making calculations during the exam and also to reduce the chances of cheating via unfair means. 

Syllabus Of Other Papers for GATE Syllabus for Biotechnology (BT) 2018

 GATE judges an aspirant’s expertise in specific fields. Aspirants can go via the syllabus of other papers as well from the table below:  

Aerospace EngineeringAEMechanical EngineeringME
Agricultural EngineeringAGMetallurgical EngineeringMT
Civil EngineeringCEMining EngineeringMN
Chemical EngineeringCHPetroleum EngineeringPE
Computer Science and Information TechnologyCSProduction and Industrial EngineeringPI
Electronics and CommunicationECTextile Engineering and Fibre ScienceTF
Electrical EngineeringEEEngineering SciencesXE
Instrumentation EngineeringIN  

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